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	Provedor de dados BJMBR (3) Autor Tatsuo,M.A.K.F. (3) Francischi,J.N. (2) Yokoro,C.M. (2) Alves,D.L.F. (1) Doretto,M.C. (1) Duarte,I.D.G. (1) Pereira,L.S.M. (1) Pesquero,S.M.S. (1) Reis,G.M.L. (1) Turchetti-Maia,R.M.M. (1) Mais... Palavra-chave Hyperalgesia (2) Adjuvant arthritis (1) Adrenalectomy (1) Audiogenic seizures (1) Dexamethasone (1) Dipyrone (1) Edema (1) Electroshock (1) Epilepsy (1) GABA-A receptors (1) Nitric oxide (1) Old rats (1) Opiates (1) Phenobarbital (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Ano 2003 (2) 2001 (1) País Brazil (3) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Acute phenobarbital administration induces hyperalgesia: pharmacological evidence for the involvement of supraspinal GABA-A receptors BJMBR Yokoro,C.M.; Pesquero,S.M.S.; Turchetti-Maia,R.M.M.; Francischi,J.N.; Tatsuo,M.A.K.F.. The aim of the present study was to determine if phenobarbital affects the nociception threshold. Systemic (1-20 mg/kg) phenobarbital administration dose dependently induced hyperalgesia in the tail-flick, hot-plate and formalin tests in rats and in the abdominal constriction test in mice. Formalin and abdominal constriction tests were the most sensitive procedures for the detection of hyperalgesia in response to phenobarbital compared with the tail-flick and hot-plate tests. The hyperalgesia induced by systemic phenobarbital was blocked by previous administration of 1 mg/kg ip picrotoxin or either 1-2 mg/kg sc or 10 ng icv bicuculline. Intracerebroventricular phenobarbital administration (5 µg) induced hyperalgesia in the tail-flick test. In contrast,... Tipo: Info:eu-repo/semantics/article Palavras-chave: Phenobarbital; Hyperalgesia; GABA-A receptors. Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000300015 Do endogenous opioids and nitric oxide participate in the anticonvulsant action of dipyrone? BJMBR Reis,G.M.L.; Doretto,M.C.; Duarte,I.D.G.; Tatsuo,M.A.K.F.. It was previously reported that systemic administration of dipyrone inhibited the tonic component of generalized tonic-clonic seizures in both the electroshock and the audiogenic seizure models. The aim of the present study was to investigate the mechanisms involved in the anticonvulsant action of dipyrone by assessing the role of nitric oxide and opioids in the electroshock (female 60- to 90-day-old Wistar rats, N = 5-11) and audiogenic seizure (female 60- to 90-day-old Wistar audiogenic rats, N = 5-11) models of epilepsy. Naloxone (5 mg/kg, sc) significantly reversed the anticonvulsant effect of dipyrone in rats submitted to the induction of audiogenic seizures (ANOVA/Bonferroni's test), suggesting the involvement of opioid peptides in this action. In... Tipo: Info:eu-repo/semantics/article Palavras-chave: Epilepsy; Dipyrone; Audiogenic seizures; Electroshock; Nitric oxide; Opiates. Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000900018 Role of endogenous glucocorticoids in hyperalgesia and edema in old arthritic rats BJMBR Yokoro,C.M.; Tatsuo,M.A.K.F.; Pereira,L.S.M.; Alves,D.L.F.; Francischi,J.N.. We compared the intensity and frequency of arthritis in old (8-12 months, N = 12) and juvenile (2 months, N = 10) rats and determined the role played by adrenal glands in this disorder. Arthritis was induced by subcutaneous injection of Mycobacterium butyricum at the base of the tail of female Holtzman rats at day zero. Paw edema and hyperalgesia were monitored from day zero to day 21 after induction as signs of arthritis development. Some (N = 11) old animals were adrenalectomized bilaterally and treated with dexamethasone or celecoxib immediately following surgery. All bilaterally adrenalectomized old animals became susceptible to arthritis and the onset of disease was shortened from the 10th to the 5th day. Hyperalgesia and paw edema responses were less... Tipo: Info:eu-repo/semantics/article Palavras-chave: Hyperalgesia; Edema; Adjuvant arthritis; Adrenalectomy; Dexamethasone; Old rats. Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000100011 Registros recuperados: 3 Primeira ... 1 ... Última

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